Chemical modification of gas-phase cluster dynamics in ion mobility spectrometry / vorgelegt von Florian Stappert. Wuppertal, April 2022
Inhalt
- 1 Introduction
- 1.1 Ion-neutral interactions in chemical analysis
- 1.1.1 Cluster dynamics
- 1.1.2 Chemical reaction
- 1.1.3 Fragmentation
- 1.1.4 Thermodynamic versus kinetic control
- 1.2 Mass spectrometry
- 1.2.1 Atmospheric pressure ionization mass spectrometry
- Electrospray ionization
- Atmospheric pressure chemical ionization
- Atmospheric pressure laser ionization
- 1.2.2 Triple quadrupole mass spectrometer
- 1.3 Ion mobility
- 1.3.1 Ion mobility spectrometry
- 1.3.2 High kinetic energy ion mobility spectrometry
- 1.3.3 Differential mobility spectrometry
- 1.4 Enantioselective analysis
- 2 Aim of this work
- 3 Experiments and methodology
- 3.1 Mass spectrometer
- 3.2 Differential mobility spectrometer
- 3.3 High kinetic energy ion mobility spectrometer
- 3.4 Chemicals and gases
- 3.5 Numerical investigations
- 4 Influence of steric properties on ion separation in DMS
- 4.1 Analyte selection and typical MS spectra
- 4.2 Influence of the ion structure on differential mobility
- 4.3 Influence of the charge level on the cluster effect
- 4.4 Summary and conclusion
- 5 Cluster dynamics under constant conditions
- 5.1 Cluster dynamics in HiKE-IMS
- 5.2 Humidity effect on cluster dynamic
- 5.3 Temperature effect on cluster dynamic
- 5.4 Chemical modification in HiKE-IMS
- 5.5 Summary and conclusion
- 6 Enantiomeric separations by stereoselective clustering
- 6.1 Preliminary measurements
- 6.1.1 Amino acids
- 6.1.2 Maruoka catalyst
- Cluster effect on the Maruoka catalyst
- Optimization of DMS temperature
- Optimization of DMS resolution
- 6.1.3 Optimized measurement parameters
- 6.2 Charged nanodroplets from ESI
- 6.3 Alternative ionization methods
- 6.3.1 Common APCI source
- 6.3.2 Custom APLI source
- 6.3.3 Common nanoESI source
- 6.3.4 Comparison and conclusion
- 6.4 Modification with enantiopure modifier
- 6.5 Numerical studies on stereoselective clustering
- 6.6 Summary and conclusion
- 7 Overall summary, conclusion, and outlook
- List of abbreviations
- List of Figures
- List of Tables
- References