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Design and characterisation of an MRI compatible human brain PET insert by means of simulation and experimental studies / vorgelegt von Mirjam Lenz. Wuppertal, 2021
Content
Introduction
Background
Introduction to PET
Historical Overview
Positron Emission
Detection of Annihilation Photons
Data Corrections
The Parallax Error
Other Factors Limiting Spatial Resolution
PET Detectors
General Detector Concept
Choosing Components for a PET Design
Crystal Geometries
Photodetectors
Philips Digital Photon Counting
Positioning Algorithms
Hybrid Imaging
MRI compatibility of the PET insert
Monte Carlo Simulations
GATE: Geant4 Application for Tomographic Emission
Motivation and Thesis Outline
Requirements for a BrainPET Scanner
Detector Concept in this Work
Objective of this Thesis
Optimisation of Detector Block Configuration
Simulation of Sensitivity in GATE
"Is it really worth it?"- A cost-benefit assessment
Impact of Capability to Detect DOI Information
Building Test Detectors
Assembly of Prototypes
Acquisition of Flood Maps
Simulation of Scintillation Photons in a Detector Block
Simulation Setting
Acquisition of Floodmaps
Simulations Including Reflectivity Quenching
GATE Digitiser Dedicated to DSiPMs
Structure of the Digitiser
Validation of the Digitiser
Results: Application to Previous Simulations
Additional Information from the Simulation
Study on Lightguide Thickness
Preliminary Study
Simulations with Different Lightguides
Comparison to Measurements with Different Lightguides
Evaluation of Reference Response for Positioning Algorithms
Maximum Likelihood Event Positioning: Workflow
Simulations: Using the Ground Truth Information
Simulation Setup
Distinguishing Signals from Different Crystal Layers
Application to Overlapping Spots
Clustering Methods
Influence of Response Functions on Positioning Results
Measurements with a Detector Block of Final Size
Flood Maps with Ground and Polished Surface Finish
Energy Resolution of Both Crystal Arrays
Spot Separability in the Final Detector Block
Conclusions and Outlook
Additional Material
Schematic Drawing of Scanner Cassettes
DPC Data Processing
Validation of the GATE Digitiser
Simulations Concerning the Reflectivity of 3M ESR Vikuiti
List of Figures
List of Tables
Bibliography