Design and characterisation of an MRI compatible human brain PET insert by means of simulation and experimental studies / vorgelegt von Mirjam Lenz. Wuppertal, 2021
Inhalt
- Introduction
- Background
- Introduction to PET
- Historical Overview
- Positron Emission
- Detection of Annihilation Photons
- Data Corrections
- The Parallax Error
- Other Factors Limiting Spatial Resolution
- PET Detectors
- General Detector Concept
- Choosing Components for a PET Design
- Crystal Geometries
- Photodetectors
- Philips Digital Photon Counting
- Positioning Algorithms
- Hybrid Imaging
- Monte Carlo Simulations
- Motivation and Thesis Outline
- Optimisation of Detector Block Configuration
- Simulation of Sensitivity in GATE
- "Is it really worth it?"- A cost-benefit assessment
- Impact of Capability to Detect DOI Information
- Building Test Detectors
- Simulation of Scintillation Photons in a Detector Block
- Simulation Setting
- Acquisition of Floodmaps
- Simulations Including Reflectivity Quenching
- GATE Digitiser Dedicated to DSiPMs
- Additional Information from the Simulation
- Study on Lightguide Thickness
- Preliminary Study
- Simulations with Different Lightguides
- Comparison to Measurements with Different Lightguides
- Evaluation of Reference Response for Positioning Algorithms
- Maximum Likelihood Event Positioning: Workflow
- Simulations: Using the Ground Truth Information
- Simulation Setup
- Distinguishing Signals from Different Crystal Layers
- Application to Overlapping Spots
- Clustering Methods
- Influence of Response Functions on Positioning Results
- Measurements with a Detector Block of Final Size
- Conclusions and Outlook
- Additional Material
- Schematic Drawing of Scanner Cassettes
- DPC Data Processing
- Validation of the GATE Digitiser
- Simulations Concerning the Reflectivity of 3M ESR Vikuiti
- List of Figures
- List of Tables
- Bibliography