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oai:elekpub.bib.uni-wuppertal.de:74399232024-03-23T12:00:03ZubwhsoaArticle

vls/2603noah-balancer_mdapi1elekpub.bib.uni-wuppertal.deperiodicalExposure to the environmentally relevant fungicide Maneb: studying toxicity in the soil nematode Caenorhabditis elegansKubens, Laura1996-VerfasserautWeishaupt, Ann-KathrinVerfasserautMichaelis, Vivien1994-VerfasserautRohn, Isabelle1992-VerfasserautMohr, Fabian1975-VerfasserautBornhorst, Julia1984-VerfasserauttextarticleTextarticlearticlegwXA-DEWuppertalUniversitätsbibliothek2024monographicengelectronic resourceremotetext/html1 Online-Ressource (10 Seiten)ComputerOnline-RessourceManeb is a manganese-containing ethylene bisdithiocarbamate fungicide and is still commonly used as no cases of resistance have been documented. However, studies have shown that Maneb exposure has neurodegenerative potential in mammals, resulting in symptoms affecting the motor system. Despite its extensive use, structural elucidation of Maneb has only recently been accomplished by our group. This study aimed to examine the bioavailability of Maneb, the quantification of oxidative stress-related endpoints and neurotransmitters employing pure Maneb, its metabolites and structural analogues, in the model organism Caenorhabditis elegans. Exposure to Maneb did not increase the bioavailability of Mn compared to manganese chloride, although Maneb was about 8 times more toxic with regard to lethality. Maneb generated not significantly reactive oxygen and nitrogen species (RONS) but decreased the ATP level while increasing the amount of glutathione and its oxidized form in a dose-dependent manner. Nevertheless, an alteration in the neurotransmitter homeostasis of dopamine, acetylcholine, and gamma-butyric acid (GABA) was observed as well as morphological changes in the dopaminergic neurons upon Maneb exposure, which underlines the assumption of the neurotoxic potential of Maneb. This study showed that Maneb exhibits effects based on a combined interaction of the ligand and manganese.adultDFG570urn:nbn:de:hbz:468-2-182910.25926/BUW/0-80210.1016/j.envint.2023.10837299373637803706441Environment InternationalAmsterdam1873-6750(DE-599)ZDB1497569-5183 (Januar 2024), Artikel 108372http://dx.doi.org/10.1016/j.envint.2023.108372http://dx.doi.org/10.1016/j.envint.2023.108372https://nbn-resolving.org/urn:nbn:de:hbz:468-2-1829Open AccessCC BY-NC-ND 4.0oaArticlepublicrda24021420251111100816.0CT009000195s2w-hsswupubwgerUBW:C:C.03Environment InternationaltextAmsterdam1873-6750(DE-599)ZDB1497569-5public https://elekpub.bib.uni-wuppertal.de//domainresource/static/graphics/connectors/viewerLogo.gifWuppertal : Bergische Universität Wuppertalcc-by-nc-nd https://ub-wuppertal.digibib.net/search/katalog/record/(DE-605)urn%3Anbn%3Ade%3Ahbz%3A468-2-1829 https://elekpub.bib.uni-wuppertal.de/id/7439923 https://elekpub.bib.uni-wuppertal.de/i3f/v20/7439923/manifest https://elekpub.bib.uni-wuppertal.de/proto_ftsearch/7439923 https://elekpub.bib.uni-wuppertal.de//domainresource/static/graphics/connectors/viewerLogo.gifWuppertal : Bergische Universität Wuppertal https://elekpub.bib.uni-wuppertal.de/id/8044300 https://elekpub.bib.uni-wuppertal.de/i3f/v20/8044300/manifest https://elekpub.bib.uni-wuppertal.de/proto_ftsearch/8044300