TY  - JOUR
AB  - Maneb is a manganese-containing ethylene bisdithiocarbamate fungicide and is still commonly used as no cases of resistance have been documented. However, studies have shown that Maneb exposure has neurodegenerative potential in mammals, resulting in symptoms affecting the motor system. Despite its extensive use, structural elucidation of Maneb has only recently been accomplished by our group. This study aimed to examine the bioavailability of Maneb, the quantification of oxidative stress-related endpoints and neurotransmitters employing pure Maneb, its metabolites and structural analogues, in the model organism Caenorhabditis elegans. Exposure to Maneb did not increase the bioavailability of Mn compared to manganese chloride, although Maneb was about 8 times more toxic with regard to lethality. Maneb generated not significantly reactive oxygen and nitrogen species (RONS) but decreased the ATP level while increasing the amount of glutathione and its oxidized form in a dose-dependent manner. Nevertheless, an alteration in the neurotransmitter homeostasis of dopamine, acetylcholine, and gamma-butyric acid (GABA) was observed as well as morphological changes in the dopaminergic neurons upon Maneb exposure, which underlines the assumption of the neurotoxic potential of Maneb. This study showed that Maneb exhibits effects based on a combined interaction of the ligand and manganese.
AU  - Kubens, Laura
AU  - Weishaupt, Ann-Kathrin
AU  - Michaelis, Vivien
AU  - Rohn, Isabelle
AU  - Mohr, Fabian
AU  - Bornhorst, Julia
DA  - 2024
DO  - 10.25926/BUW/0-802
PB  - Universitätsbibliothek
DP  - Bergische Universität Wuppertal
LA  - eng
N1  - Gesehen am 22.03.2024
PY  - 2024
SN  - 1873-6750
SP  - 1 Online-Ressource (10 Seiten)
T2  - Environment International
TI  - Exposure to the environmentally relevant fungicide Maneb: studying toxicity in the soil nematode Caenorhabditis elegans
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:468-2-1829
Y2  - 2024-12-21T18:30:17
ER  -